Plasma medicine is a young, interdisciplinary research fi eld in which physics, medicine and chemistry meet. Plasma is also referred to as a fourth aggregate state and is a partial ionized gas which, due to its electrical conductivity, has particular properties which can be used medically. The main active components of the plasma are reactive nitrogen and oxygen species, UV radiation and electric fi elds. The same synergetic mechanisms of action are already known as therapeutic approaches and play a decisive role in wound healing processes. First studies showed a wound healing and antimicrobial effect of cold plasma when applied to human skin already in the 1970s. In the human area, positive results have been scientifi cally demonstrated, especially in the treatment of infectious and inflammatory skin diseases and chronic wounds. Cold plasma stimulates the treated tissue in addition to the regeneration and additionally has a pain-relieving effect.